The NRDDB facilitates and supports the development of small and medium size enterprise (SMEs). This is done in various ways including finding partnerships to support the provision of technical, business, administrative and management services which could help to advance existing enterprises. The NRDDB also supports innovative enterprises.
The NRDDB has recently been working with other partners to develop  North Rupununi Tourism Programme (NRTP); ) Ornamental Aquarium Fisheries Initiative,  Traditional Arts and Craft Design; and the Medicine from Trees enterprises.